https://nova.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:8273 Sat 24 Mar 2018 08:33:28 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:2826 Sat 24 Mar 2018 08:28:24 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:12950 1) between patient cohorts receiving specialised care for different lengths of time. Results: Improved mean height z-score (−0.880 v −0.047) and weight centile (28.3% v 48.1%) for the 10–15 year age group in 1997, who had received continuous lifetime care within the clinic, compared with the same age group in 1993, for whom continuous medical care started at an older age. There was no corresponding improvement in FEV₁, as an indicator of lung function, in this group (81.6% predicted v 89.5% predicted). Conclusions: This study suggests that lifetime continuous care within a specialised CF centre is associated with improved growth but not improved lung function.]]> Sat 24 Mar 2018 08:18:29 AEDT ]]> https://nova.newcastle.edu.au/vital/access/ /manager/Repository/uon:31059 45 days, change in length z scores within 3 months of HPE, and center. On multivariate analysis, TB (P < 0.0001) and albumin (P=0.02) at 3 months post-HPE, and center (P=0.0003) were independently associated with native liver survival. Receiver operating characteristic analysis revealed an optimal cut-off value of TB < 74 µmol/L (4.3 mg/dL; area under the receiver operating characteristic curve 0.8990) and serum albumin level > 35 g/L (3.5 mg/dL; area under the receiver operating characteristic curve 0.7633) to predict 2-year native liver survival. TB and albumin levels 3 months post-HPE defined 3 groups (1: TB =74 µmol/L, albumin > 35 g/L; 2: TB =74 µmol/L, albumin =35 g/L; 3: TB > 74 µmol/L) with distinct short-and long-term native liver survival rates (log-rank P < 0.001). Length z scores 3 months post-HPE were poorer for group 2 than group 1 (-0.91 vs-0.30, P=0.0217) with similar rates of coagulopathy. Conclusions: Serum TB and albumin levels 3 months post-HPE independently predicted native liver survival in BA when controlling for center. Serum albumin level < 35 g/L in infants with BA who were no longer jaundiced at 3 months post-HPE was a poor prognostic indicator. Poorer linear growth and absence of significant coagulopathy suggest a role for early aggressive nutritional therapy in this group.]]> Sat 24 Mar 2018 07:25:47 AEDT ]]>